Antimicrobial Resistance - Part 1
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The GRAPHALO Trial: A double blind, randomised, placebo controlled, feasibility trial evaluating the possibility of delivering AndroGRAPHis pAnicuLata as a treatment Of adults with Acute Respiratory Tract Infections (ARTIs)
Introduction: ARTIs such as cough, sore throat and sinusitis are common, distressing, and costly both for individuals and the NHS. Antibiotics have limited benefits in most ARTIs and commonly have side effects. A herbal medicine called Andrographis (Andrographis paniculata) is a promising candidate to treat ARTIs. In a recent systematic review of randomised controlled trials, Andrographis performed better than placebo after 5-7 days. The primary study objective was to measure feasibility outcomes to inform the design of a future fully powered trial of Andrographis leaf extract as an alternative to antibiotics for upper respiratory tract infections in UK primary care.
Prof Michael Moore, University of Southampton; Dr Miriam Santer, Associate Professor, University of Southampton; Dr Andrew Flower, Senior Research Fellow, Jade Screen Project; Dr Beth Stuart, Associate Professor, University of Southampton; Jackie Seely, Patient and Public Involvement Offier, University of Southampton